Article
Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus.
The Journal of antimicrobial chemotherapy - 1 Jun 2008
Kumar Ashwani, Khan Inshad Ali, Koul Surrinder, Koul Jawahir Lal, Taneja Subhash Chandra, Ali Intzar, Ali Furqan, Sharma Sandeep, Mirza Zahid Mehmood, Kumar Manoj, Sangwan Pyare Lal, Gupta Pankaj, Thota Niranjan, Qazi Ghulam Nabi
Abstract excerpt
OBJECTIVES: Evaluation of novel synthetic analogues of piperine as inhibitors of multidrug efflux pump NorA of Staphylococcus aureus. METHODS: A library of piperine-derived compounds was evaluated for their potential to inhibit ethidium bromide efflux in NorA-overexpressing S. aureus SA 1199B. The active compounds were then individually combined with ciprofloxacin to study the potentiation of ciprofloxacin's...
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