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Article

Human fortilin is a molecular target of dihydroartemisinin

4 Mar 2008

Abstract excerpt

Dehydroartemisinin (DHA) is an effective anti-malaria agent. Fortilin is an anti-apoptotic molecule overexpressed in many human cancers. Here, we show that DHA binds human fortilin, increases the ubiquitination of fortilin, shortens fortilin's half-life in a proteasome-dependent fashion, and reduces cellular levels of fortilin in varieties of cells. DHA induced DNA fragmentation in U2OS cells in a...

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PMID: 18325342
DOI: 10.1016/j.febslet.2008.02.055

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