Article
Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome.
Arthritis and rheumatism - 1 Mar 2008
Yamazaki Takashi, Masumoto Junya, Agematsu Kazunaga, Sawai Nobukuni, Kobayashi Shinji, Shigemura Tomonari, Yasui Kozo, Koike Kenichi
Abstract excerpt
Muckle-Wells syndrome (MWS) is a dominantly inherited autoinflammatory syndrome. Patients with MWS have a mutation in CIAS1, the gene encoding cryopyrin, a component of the inflammasome that regulates the processing of interleukin-1beta (IL-1beta). In this report we describe an 8-year-old Japanese girl with MWS who had symptoms of periodic fever, urticarial rash, conjunctivitis, arthropathy, and sensory deafness....
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