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Article

Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP.

Biochimica et biophysica acta - 1 Apr 2008

Mao Guozhang, Tan Jianxin, Gao Wei, Shi Yongchang, Cui Mei-Zhen, Xu Xuemin

Abstract excerpt

Presenilin-associated protein (PSAP) was originally identified as a PS1-associated, PDZ domain protein. In a subsequent study, PSAP was found to be a mitochondrial apoptotic molecule. In this study, we cloned the PSAP gene and found that it is composed of 12 exons and localizes on chromosome 6. To better understand the structure and function of PSAP, we have generated a series of antibodies that recognize...

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Source

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Identifiers

PMID: 18291114
DOI: 10.1016/j.bbagen.2008.01.013
PMCID: PMC3509497

Genes

PSAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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