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Article

Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane.

American journal of physiology. Cell physiology - 1 Oct 2007

Lamarca Violeta, Sanz-Clemente Antonio, Pérez-Pé Rosaura, Martínez-Lorenzo María José, Halaihel Nabil, Muniesa Pedro, Carrodeguas José A

Abstract excerpt

Presenilin 1-associated protein (PSAP) was first identified as a protein that interacts with presenilin 1. It was later reported that PSAP is a mitochondrial protein that induces apoptosis when overexpressed in cultured cells. PSAP is also known as mitochondrial carrier homolog 1 (Mtch1). In this study, we show that there are two proapoptotic PSAP isoforms generated by alternative splicing that differ in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17670888
DOI: 10.1152/ajpcell.00431.2006

Genes

PSAP
MTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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