Article
A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico.
Genetics and molecular research : GMR - 8 Jan 2008
García-Ortiz L, Vargas-Alarcón G, Fragoso J M, Granados J, Maldonado Noriega L, Navas Pérez A, Huerta Reyes E, Zenteno-Ruiz J C, Martínez-Cordero E
Abstract excerpt
The human orosomucoid 1 gene (ORM1) codes an alpha-1-acid glycoprotein that has been classified as an acute-phase reactive protein, and a major drug-binding serum component, as well as an immunomodulatory protein with genetic polymorphisms. Evaluation of ORM variation through isoelectric focusing and immunobloting has revealed a world-wide distribution of the ORM1 F and ORM1 S alleles. We evaluated and examined...
Topics
- Alleles
- DNA
- Exons
- Gene Frequency
- Genetic Variation
- Genetics, Population
- Humans
- Indians, North American
- Mexico
- Orosomucoid
- Polymerase Chain Reaction