Article
High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population.
Molecular genetics & genomic medicine - 1 Feb 2021
Gutiérrez-Franco Jorge, Ayón-Pérez Miriam Fabiola, Durán-Avelar Ma de Jesús, Vibanco-Pérez Norberto, Sánchez-Jasso Diego Eduardo, Bañuelos-Aguayo Dulce Guadalupe, Sánchez-Meza Jaime, Pimentel-Gutiérrez Helia Judith, Zambrano-Zaragoza José Francisco, Agraz-Cibrián Juan Manuel, Vázquez-Reyes Alejandro
Abstract excerpt
BACKGROUND: IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs4132601 (T>G) and rs11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the rs4132601 and rs11978267 polymorphisms in two indigenous Mexican groups (Cora and...