Article
Evaluation of linkage disequilibrium on the Xq13.3 region: comparison between the Azores islands and mainland Portugal.
American journal of human biology : the official journal of the Human Biology Council - 1 Jan 2000
Branco Claudia C, Cabrol Ester, São Bento Marta, Gomes Cidália T, Cabral Rita, Vicente Astrid M, Pacheco Paula R, Mota-Vieira Luisa
Abstract excerpt
The design of genetic studies of complex diseases is dependent on the extent and distribution of linkage disequilibrium (LD) across the genome in different populations. Here, we characterize the extent of LD in the Azores (Western, Central, and Eastern island groups) and mainland Portugal populations. LD was evaluated in the Xq13.3 region by genotyping eight STR markers spanning 20.9 Mb. Standardized multiallelic...
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