Article
Phase-locked mutants of Mycoplasma agalactiae: defining the molecular switch of high-frequency Vpma antigenic variation.
Molecular microbiology - 1 Mar 2008
Chopra-Dewasthaly Rohini, Citti Christine, Glew Michelle D, Zimmermann Martina, Rosengarten Renate, Jechlinger Wolfgang
Abstract excerpt
Mycoplasma agalactiae, an important pathogen of small ruminants, exhibits antigenic diversity by switching the expression of multiple surface lipoproteins called Vpmas (Variable proteins of M. agalactiae). Although phase variation has been shown to play important roles in many host-pathogen interactions, the biological significance and the mechanism of Vpma oscillations remain largely unclear. Here, we...
Topics
- Antigenic Variation
- Bacterial Proteins
- Blotting, Western
- Gene Order
- Genetic Complementation Test
- Mutation
- Mycoplasma agalactiae
- Open Reading Frames
- Recombinases
- Recombination, Genetic