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Article

Real-time detection and quantification of mitochondrial mutations with oligonucleotide primers containing locked nucleic acid.

Clinica chimica acta; international journal of clinical chemistry - 1 Apr 2008

Strand Harald, Ingebretsen Ole Christian, Nilssen Oivind

Abstract excerpt

BACKGROUND: The phenotypic expression of disorders caused by point mutations, deletions or depletions within the mitochondrial genome (mtDNA) is heterogeneous. This relates to the phenomena of heteroplasmy, tissue threshold as well as the distribution of mutant DNA among tissues. Hence, the diagnostics of these disorders demands highly specific, sensitive and quantitative methods. METHODS: We have developed an...

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PMID: 18241671
DOI: 10.1016/j.cca.2008.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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