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Article

Genotype-phenotype analysis and natural history of left ventricular hypertrophy in LEOPARD syndrome.

American journal of medical genetics. Part A - 1 Mar 2008

Limongelli Giuseppe, Sarkozy Anna, Pacileo Giuseppe, Calabrò Paolo, Digilio Maria Cristina, Maddaloni Valeria, Gagliardi Giulia, Di Salvo Giovanni, Iacomino Maria, Marino Bruno, Dallapiccola Bruno, Calabrò Raffaele

Abstract excerpt

Because it is unclear whether the genotype may influence the clinical course in patients with LEOPARD syndrome (LS), we analyzed clinical and molecular predictors of adverse cardiac events in patients with left ventricular hypertrophy (LVH). A comprehensive cardiovascular evaluation, including baseline electrocardiogram, echocardiography, exercise test and 24 hr Holter monitoring at the time of clinical diagnosis...

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Topics

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Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertrophy, Left Ventricular

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Source

Identifiers

PMID: 18241070
DOI: 10.1002/ajmg.a.32206

Genes

PTPN11
RAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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