Article
Mutations in NALP12 cause hereditary periodic fever syndromes.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2008
Jéru I, Duquesnoy P, Fernandes-Alnemri T, Cochet E, Yu J W, Lackmy-Port-Lis M, Grimprel E, Landman-Parker J, Hentgen V, Marlin S, McElreavey K, Sarkisian T, Grateau G, Alnemri E S, Amselem S
Abstract excerpt
NALP proteins, also known as NLRPs, belong to the CATERPILLER protein family involved, like Toll-like receptors, in the recognition of microbial molecules and the subsequent activation of inflammatory and immune responses. Current advances in the function of NALPs support the recently proposed model of a disease continuum bridging autoimmune and autoinflammatory disorders. Among these diseases, hereditary...
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