Article
Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation.
Biochemical and biophysical research communications - 28 Mar 2008
Suzuki Tsukasa, Das Swadesh K, Inoue Hirohumi, Kazami Machiko, Hino Okio, Kobayashi Toshiyuki, Yeung Raymond S, Kobayashi Ken-Ichi, Tadokoro Tadahiro, Yamamoto Yuji
Abstract excerpt
The products of the TSC1 (hamartin) and TCS2 (tuberin) tumor suppressor genes negatively regulate cell growth by inhibiting mTOR signaling. Recent research has led to the postulation that tuberin and/or hamartin are involved in tumor migration, presumably through Rho activation. Here we show that LEF-8 cells, which contain a Y1571 missense mutation in tuberin, express higher Rac1 activity than tuberin negative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.