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Article

Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.

The Journal of biological chemistry - 15 Jun 2001

Aicher L D, Campbell J S, Yeung R S

Abstract excerpt

Hamartin and tuberin are products of the tumor suppressor genes, TSC1 and TSC2, respectively. When mutated, a characteristic spectrum of tumor-like growths develop resulting in the syndrome of tuberous sclerosis complex. The phenotypes associated with TSC1 and TSC2 mutations are largely indisting...

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Source

Identifiers

PMID: 11290735
DOI: 10.1074/jbc.C100136200

Genes

TSC2
TSC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11290735-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.PMID 11290735Read ↗

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.Semantic proximity Read ↗

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin.Semantic proximity Read ↗

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene productsSemantic proximity Read ↗

The TSC1 gene product, hamartin, negatively regulates cell proliferationSemantic proximity Read ↗

Characterization of the Cytosolic Tuberin-Hamartin ComplexSemantic proximity Read ↗

Identification and characterization of the interaction between tuberin and 14-3-3zeta.Semantic proximity Read ↗

TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis.Semantic proximity Read ↗

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitinationSemantic proximity Read ↗

Tumour suppressors hamartin and tuberin: intracellular signalling.Semantic proximity Read ↗

Molecular genetic basis of tuberous sclerosis complex: from bench to bedside.Semantic proximity Read ↗

Proteins interacting with the tuberous sclerosis gene products.Semantic proximity Read ↗

Phosphorylation of Tuberin as a Novel Mechanism for Somatic Inactivation of the Tuberous Sclerosis Complex Proteins in Brain LesionsSemantic proximity Read ↗

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