Article
Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation.
Pediatric transplantation - 1 May 2008
Furue Takeki, Hattori Motoshi, Tsukaguchi Hiroyasu, Kitamura Akiko, Oomori Tae, Ogino Daisuke, Nakakura Hyogo, Ashida Akira, Miura Kenichiro, Hisano Masataka, Takahashi Kazuhiro, Chikamoto Hiroko, Akioka Yuko, Sakano Takashi
Abstract excerpt
Recurrent FSGS is a major challenge in the field of nephrology. To clarify the role of NPHS2 defects in the pathogenesis of FSGS recurrence, we sequenced all eight exons of NPHS2 in 11 Japanese pediatric FSGS patients with or without post-transplant recurrence. All patients had biopsy-proven primary FSGS, had no family history of renal diseases or consanguinity, were steroid-resistant, and received living-related...
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