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Article

In silico detection of sequence variations modifying transcriptional regulation.

PLoS computational biology - 1 Jan 2008

Andersen Malin C, Engström Pär G, Lithwick Stuart, Arenillas David, Eriksson Per, Lenhard Boris, Wasserman Wyeth W, Odeberg Jacob

Abstract excerpt

Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked to genetic diseases, most identified causal mutations alter an encoded protein sequence. Technological advances for measuring RNA abundance suggest that a significant number of undiscovered...

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Identifiers

PMID: 18208319
DOI: 10.1371/journal.pcbi.0040005
PMCID: PMC2211530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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