Article
Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis.
Virchows Archiv : an international journal of pathology - 1 Mar 2008
Küsters-Vandevelde Heidi V N, Keunen Jan E E, Wesseling Pieter, Verdijk Marian A J, Ligtenberg Marjolijn J L, Blokx Willeke A M
Abstract excerpt
The differential diagnosis between primary uveal melanoma and cutaneous melanoma metastasis in the eye may be difficult, both clinically and histologically. We report successful application of combined mutational analysis of the NRAS and the CDKN2A gene to discriminate between these two entities....
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