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Article

P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle.

Development (Cambridge, England) - 1 Feb 2008

Shimomura Yutaka, Wajid Muhammad, Shapiro Lawrence, Christiano Angela M

Abstract excerpt

P-cadherin is a member of the classical cadherin family that forms the transmembrane core of adherens junctions. Recently, mutations in the P-cadherin gene (CDH3) have been shown to cause two inherited diseases in humans: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome). The common features of both diseases are sparse hair and macular...

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Share to Cadherins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18199584
DOI: 10.1242/dev.006718

Genes

CDH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle.PMID 18199584Read ↗

Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome).Semantic proximity Read ↗

Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin.Semantic proximity Read ↗

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 LocusSemantic proximity Read ↗

Novel CDH3 mutations in hypotrichosis with juvenile macular dystrophySemantic proximity Read ↗

Hypotrichosis with juvenile macular dystrophy: a case report with molecular study.Semantic proximity Read ↗

Deletion of p63 exon 13 in mice reveals C-terminal isoform–specific functions in epithelial developmentSemantic proximity Read ↗

p63 in skin appendage development.Semantic proximity Read ↗

A novel splice-acceptor site mutation in CDH3 gene in a consanguineous family exhibiting hypotrichosis with juvenile macular dystrophy.Semantic proximity Read ↗

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiationSemantic proximity Read ↗

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.Semantic proximity Read ↗

The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits.Semantic proximity Read ↗

Phenotypic diversity and mutation spectrum in hypotrichosis with juvenile macular dystrophy.Semantic proximity Read ↗

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