Article
Altered macroautophagy in the spinal cord of SOD1 mutant mice.
Autophagy - 1 Apr 2008
Li Liang, Zhang Xiaojie, Le Weidong
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by selective loss of motor neurons (MNs). About 20% familial cases of ALS (fALS) carried the Cu, Zn-superoxide dismutase (SOD1) gene mutation, which plays a crucial role in the pathogenesis of fALS. There is evidence suggesting that macroautophagy can degrade mutated SOD1 in vitro. To investigate whether the mutant SOD1 can induce...
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