Article
Soluble syndecan-1 (sCD138) as a prognostic factor independent of mutation status in patients with chronic lymphocytic leukemia.
International journal of laboratory hematology - 1 Feb 2009
Jilani I, Wei C, Bekele B N, Zhang Z J, Keating M, Wierda W, Ferrajoli A, Estrov Z, Kantarjian H, O'Brien S M, Giles F J, Albitar M
Abstract excerpt
Syndecan-1 (sCD138) is a transmembrane heparan sulfate-bearing proteoglycan expressed in epithelial cells as well as hematopoietic cells that demonstrate plasmacytoid differentiation. Higher levels of sCD138 correlate with poor outcome in myeloma. We examined the association of circulating sCD138 levels in plasma with clinical behavior in 104 patients with chronic lymphocytic leukemia. sCD138 levels were...
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