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Article

Lactose and lactase--who is lactose intolerant and why?

Journal of pediatric gastroenterology and nutrition - 1 Dec 2007

Montgomery Robert K, Krasinski Stephen D, Hirschhorn Joel N, Grand Richard J

Abstract excerpt

Lactase-phlorizin hydrolase (LPH) is expressed only in the small intestine and is confined to absorptive enterocytes on the villi with a tightly controlled pattern of expression along the proximal to distal and crypt-villus axes of the intestine. LPH expression is regulated mainly at the level of lactase (LCT) gene transcription that directs 2 phenotypes: a decline in LCT activity (LCT nonpersistence) in...

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Topics

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Share to Gene Expression Regulation, Enzymologic
Share to LCT gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genotype

Share to Intestine, Small

Share to Lactase

Share to Lactose

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18185074
DOI: 10.1097/MPG.0b013e31812e68f6

Genes

LCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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