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Article

IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function.

The Journal of allergy and clinical immunology - 1 Apr 2008

Salt Bryn H, Niemela Julie E, Pandey Rahul, Hanson Eric P, Deering Raquel P, Quinones Ralph, Jain Ashish, Orange Jordan S, Gelfand Erwin W

Abstract excerpt

BACKGROUND: Patients with hypomorphic nuclear factor-kappaB essential modulator (NEMO) mutations have extensive phenotypic variability that can include atypical infectious susceptibility. OBJECTIVE: This study may provide important insight into immunologic mechanisms of host defense. METHODS: Immunologic evaluation, including studies of Toll-like receptor (TLR) function, was performed in a 6-month-old boy with...

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Share to I-kappa B Kinase
Share to Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Killer Cells, Natural

Share to Opportunistic Infections

Share to Pneumocystis carinii

Share to Pneumonia, Pneumocystis

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Source

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Identifiers

PMID: 18179816
DOI: 10.1016/j.jaci.2007.11.014
PMCID: PMC3050055

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IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function.PMID 18179816Read ↗

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