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Article

Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia.

Biochemical and biophysical research communications - 29 Feb 2008

Suzuki Toshimitsu, Inoue Ikuyo, Yamagata Tetsushi, Morita Noriyuki, Furuichi Teiichi, Yamakawa Kazuhiro

Abstract excerpt

EFHC1 is a gene mutated in patients with idiopathic epilepsies, and encodes the myoclonin1 protein. We here report the distribution of myoclonin1 in mouse. Immunohistochemical analyses revealed that the myoclonin1 first appeared at the roof of hindbrain at embryonic day 10 (E10), and moved on to choroid plexus at E14. At E18, it moved to ventricle walls and disappeared from choroid plexus. From neonatal to adult...

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Source

Identifiers

PMID: 18164683
DOI: 10.1016/j.bbrc.2007.12.126

Genes

EFHC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia.PMID 18164683Read ↗

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Re-evaluation of myoclonin1 immunosignals in neuron, mitotic spindle, and midbody--nonspecific?Semantic proximity Read ↗

Epilepsy protein myoclonin1 interacts with inositol 1,4,5–trisphosphate (IP <sub>3</sub> ) receptor and reduces Ca <sup>2+</sup> store in endoplasmic reticulumSemantic proximity Read ↗

The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagellaSemantic proximity Read ↗

Juvenile myoclonic epilepsy as a possible neurodevelopmental disease: role of EFHC1 or Myoclonin1.Semantic proximity Read ↗

Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.Semantic proximity Read ↗

Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development.Semantic proximity Read ↗

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EFHC1, a protein mutated in juvenile myoclonic epilepsy, associates with the mitotic spindle through its N-terminus.Semantic proximity Read ↗

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EFHC1 interacts with microtubules to regulate cell division and cortical development.Semantic proximity Read ↗

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