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Article

Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186.

Archiv der Pharmazie - 1 Jan 2008

El-Brollosy Nasser R, Sørensen Esben R, Pedersen Erik B, Sanna Giuseppina, La Colla Paolo, Loddo Roberta

Abstract excerpt

The present study describes the synthesis and antiviral evaluation of a series of novel 6-(3-trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of the HIV drugs emivirine and GCA-186. The objective was to investigate whether the fluoro or trifluoromethyl substituents could lead to an improved antiviral activity against HIV-1 wild type and mutants resistant to non-nucleoside RT inhibitors. The biological test...

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Identifiers

PMID: 18161905
DOI: 10.1002/ardp.200700113

Genes

GCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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