Article
Reverse transcriptase mutations in Cambodian CRF01_AE isolates after antiretroviral prophylaxis against HIV Type 1 perinatal transmission.
AIDS research and human retroviruses - 1 Dec 2007
Ly Nary, Phoung Viseth, Min Duong Chan, Srey Chanthan, Kruy Leang Sim, Koum Kanal, Chhum Vannarith, Glaziou Philippe, Fleury Hervé J, Reynes Jean-Marc
Abstract excerpt
This study explores amino acid changes of the reverse transcriptase (rt) of CRF01_AE isolates from pregnant women naive to antiretroviral drugs before and 2, 6, and 52 weeks after exposure to single dose nevirapine (sdNVP). Results based on 51 observations showed that the proportion of isolates with nonnucleoside reverse transcriptase inhibitor (NNRTI) RMs in the group treated with sdNVP (n = 35) increased from...
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