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mtDNA variation predicts population size in humans and reveals a major Southern Asian chapter in human prehistory.

Molecular biology and evolution - 1 Feb 2008

Atkinson Quentin D, Gray Russell D, Drummond Alexei J

Abstract excerpt

The relative timing and size of regional human population growth following our expansion from Africa remain unknown. Human mitochondrial DNA (mtDNA) diversity carries a legacy of our population history. Given a set of sequences, we can use coalescent theory to estimate past population size through time and draw inferences about human population history. However, recent work has challenged the validity of using...

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PMID: 18093996
DOI: 10.1093/molbev/msm277

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