Article
The elucidation of KIR2DL4 gene polymorphism.
Molecular immunology - 1 Apr 2008
Schellekens Jennifer, Tilanus Marcel G J, Rozemuller Erik H
Abstract excerpt
The killer cell immunoglobulin-like receptors (KIRs) on NK cells recognize defined groups of HLA class I alleles. By this mechanism the NK cells fulfil a significant role in the first line of defense against infectious agents and cancer. For the treatment of leukaemia this NK cell allorecognition is of great importance. Still, an appropriate effect against the leukaemic cells requires sufficient expression of...
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