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Article

Derivation, Characterization, and In Vitro Differentiation of Canine Embryonic Stem Cells

6 Dec 2007

Abstract excerpt

Canine embryonic stem (cES) cell lines were generated to establish a large-animal preclinical model for testing the safety and efficacy of embryonic stem (ES) cell-derived tissue replacement therapy. Putative cES cell lines were initiated from canine blastocysts harvested from natural matings. Times of harvest were estimated as 12-16 days after the presumed surge in circulating levels of luteinizing hormone. Four...

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PMID: 18065395
DOI: 10.1634/stemcells.2007-0640

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