Article
Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome.
Intensive care medicine - 1 Mar 2008
Villar Jesús, Flores Carlos, Pérez-Méndez Lina, Maca-Meyer Nicole, Espinosa Elena, Blanco Jesús, Sangüesa Ruben, Muriel Arturo, Tejera Paula, Muros Mercedes, Slutsky Arthur S
Abstract excerpt
OBJECTIVE: The insertion/deletion (I/D) of a 289 base pair Alu repeat sequence polymorphism in the angiotensin-converting enzyme gene (ACE) has been shown to predict susceptibility and outcome in the acute respiratory distress syndrome (ARDS). We hypothesized that the I/D polymorphism also confers susceptibility to sepsis and is a predisposing factor for morbidity and mortality of patients with severe sepsis....
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