HLA Class I Gene Polymorphism in Iranian Patients with Papillon-Lefevre Syndrome

Abstract excerpt

BACKGROUND: Papillon-Lefevre Syndrome (PLS) is a rare autosomal recessive disorder characterized by diffused palmoplantar keratoderma and severe periodontitis. Increased susceptibility to infections due to impairment of the immune system is considered to be involved in pathoetiology of this disease. OBJECTIVES: According to the crucial function of HLA molecules in immune responses and association between certain...

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