Article
Mapping of Papillon-Lefevre syndrome to the chromosome 11q14 region.
European journal of human genetics : EJHG - 1 Jan 2000
Fischer J, Blanchet-Bardon C, Prud'homme J F, Pavek S, Steijlen P M, Dubertret L, Weissenbach J
Abstract excerpt
Papillon-Lefevre syndrome (PLS) is an autosomal recessive disease which belongs to the palmo-plantar keratoderma (PPK) group. It is characterized by a premature loss of primary and permanent teeth and early onset periodontitis. High consanguinity has been observed in over one-third of PLS families. No candidate genes or gene localizations have been described to date for this disorder. A primary genome-wide search...
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