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Article

A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007

Jarosinski Keith, Kattenhorn Lisa, Kaufer Benedikt, Ploegh Hidde, Osterrieder Nikolaus

Abstract excerpt

The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a protease domain embedded in the large tegument protein of herpes simplex virus 1 (HSV-1), is conserved across all members of the Herpesviridae. Whether this conservation is indicative of an essential function of the enzyme in vivo has not yet been established. As reported here, USP activity is conserved in Marek's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18056809
DOI: 10.1073/pnas.0706295104
PMCID: PMC2148416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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