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Cytokines and β-Cell Biology: from Concept to Clinical Translation

29 Nov 2007

Abstract excerpt

The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate...

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PMID: 18048762
DOI: 10.1210/er.2007-0033

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