Article
Hyperproduction of sebaceous cis-6-hexadecenoic acid by esterase-reduced mutant of Rhodococcus sp. strain.
Journal of bioscience and bioengineering - 1 Oct 2007
Araki Hiroyuki, Hagihara Hiroshi, Takigawa Hirofumi, Kotani Nobuharu, Tsujino Yukiharu, Koike Kenzo, Kawai Shuji, Ozaki Katsuya, Ito Susumu
Abstract excerpt
cis-6-Hexadecenoic acid is a major component of human sebaceous lipids that is involved in skin self-sterilization and atopic dermatitis amelioration. It can be prepared by hydrolysis of isopropyl cis-6-hexadecenoate produced by resting cells of Rhodococcus sp. strain KSM-MT66. To devise an economical industrial-scale process for the production of this rare fatty acid, we optimized the conditions for growing...
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