Article
A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation.
American journal of human genetics - 1 Dec 2007
Mio Futoshi, Chiba Kazuhiro, Hirose Yuichiro, Kawaguchi Yoshiharu, Mikami Yasuo, Oya Takeshi, Mori Masaki, Kamata Michihiro, Matsumoto Morio, Ozaki Kouichi, Tanaka Toshihiro, Takahashi Atsushi, Kubo Toshikazu, Kimura Tomoatsu, Toyama Yoshiaki, Ikegawa Shiro
Abstract excerpt
Lumbar disc herniation (LDH), degeneration and herniation of the nucleus pulposus of the intervertebral disc (IVD) of the lumbar spine, is one of the most common musculoskeletal diseases. Its etiology and pathogenesis, however, remain unclear. Type XI collagen is important for cartilage collagen formation and for organization of the extracellular matrix. We identified an association between one of the type XI...
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