Article
Mutational analysis of the human MBX gene in four Korean families demonstrating microphthalmia with congenital cataract.
The Turkish journal of pediatrics - 1 Jan 2000
Miyamoto Toshinobu, Yu Young S, Sato Hisashi, Hayashi Hiroaki, Sakugawa Naoko, Ishikawa Mutsuo, Sengoku Kazuo
Abstract excerpt
The MBX gene is a novel paired-type homeobox gene. It plays a number of critical roles in the development of the eyes in the zebrafish. The knockdown of the mbx expression by morpholino antisense oligonucleotides leads to a reduction in the size of eyes and tectum in the zebrafish. We investigated whether the human MBX gene was associated with susceptibility to microphthalmia by analyzing four Korean families...
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