Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells

1 Dec 2007

Abstract excerpt

Reversine (RV) is the synthetic purine identified from a protein kinase-based screen of purine mimetics and it has been shown to induce muscle myoblast differentiation into progenitor cells that can be further converted into other cell lineages. Since protein kinases play a pivotal role in cell cycle control, we hypothesize that RV might affect the proliferation of cancer cells. Herein we report that RV inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to HIV/AIDS drug development and treatment
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17982654
DOI: 10.3892/ijo.31.6.1293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cellsPMID 17982654Read ↗

Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cellsSemantic proximity Read ↗

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cellsSemantic proximity Read ↗

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) CellsSemantic proximity Read ↗

Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell linesSemantic proximity Read ↗

Identification of small-molecule inducers of pancreatic β-cell expansionSemantic proximity Read ↗

Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.Semantic proximity Read ↗

Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.Semantic proximity Read ↗

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.