Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.

Abstract excerpt

BACKGROUND: Previously, we reported that a novel fusion protein consisting of an amino-terminal fragment of urokinase linked to the amino terminus of the enzyme L-methioninase inhibited MCF-7 breast cancer cells in vitro to a greater extent than treatment with L-methioninase. MATERIALS AND METHODS: The fusion protein, L-methioninase and a mutated fusion protein without L-methioninase activity were produced by...

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