Article
UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese.
Drug metabolism and pharmacokinetics - 1 Oct 2007
Honda Mutsuko, Toyoda Wakako, Shimizu Takako, Horiuchi Isao, Kayano Yuichiro, Taguchi Masato, Nozawa Takashi, Inoue Hiroshi, Hashimoto Yukiya
Abstract excerpt
We previously investigated the pharmacokinetics of R- and S-carvedilol in 54 healthy Japanese subjects, and reported that the oral clearance (CL/F) and apparent volume of distribution (V/F) of both enantiomers in subjects with the CYP2D6*10 allele were significantly lower than those in subjects without the CYP2D6*10 allele. In the present study, we examined the genotype of UGT2B7 in these 54 subjects, and...
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