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Article

CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

Clinical pharmacology and therapeutics - 1 Mar 2004

Giessmann Thomas, Modess Christiane, Hecker Ute, Zschiesche Michael, Dazert Peter, Kunert-Keil Christiane, Warzok Rolf, Engel Georg, Weitschies Werner, Cascorbi Ingolf, Kroemer Heyo K, Siegmund Werner

Abstract excerpt

BACKGROUND: Clinical trials have indicated that the combined beta- and alpha-adrenergic receptor blocker carvedilol improves the survival rate in patients with advanced chronic heart failure. The objective of our study was the identification and quantification of factors that modulate steady-stat...

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Identifiers

PMID: 15001973
DOI: 10.1016/j.clpt.2003.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15001973-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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