Article
Phenotypic variability in human embryonic holoprosencephaly in the Kyoto Collection.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2004
Yamada Shigehito, Uwabe Chigako, Fujii Shingo, Shiota Kohei
Abstract excerpt
BACKGROUND: Holoprosencephaly (HPE) is one of the most common developmental disorders of the brain associated with specific craniofacial dysmorphogenesis. Although numerous postnatal cases have been reported, early phases of its pathogenesis are not well understood. We examined over 200 cases of HPE human embryos both grossly and histologically, and studied their phenotypic variability and stage-specific...
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