Article
Vascular endothelial growth factor +936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population.
Acta obstetricia et gynecologica Scandinavica - 1 Jan 2007
Ikuhashi Yoshiyuki, Yoshida Shigeki, Kennedy Stephen, Zondervan Krina, Takemura Naoya, Deguchi Masashi, Ohara Noriyuki, Maruo Takeshi
Abstract excerpt
BACKGROUND: Vascular endothelial growth factor (VEGF) concentration in endometriosis patients is higher than controls, in serum and ascites, suggesting that VEGF may play an important role in the pathogenesis of endometriosis. In this study, we investigated whether polymorphisms in the VEGF gene are associated with endometriosis in a Japanese population. METHODS: Genotyping of VEGF -460 C/T, +405 G/C and +936 C/T...
Topics
- Adult
- Asian People
- Case-Control Studies
- Endometriosis
- Female
- Genetic Predisposition to Disease
- Humans
- Infant, Newborn
- Linkage Disequilibrium
- Polymorphism, Genetic
