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Article

Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007

Thomas Sharyn, Xue Shao-An, Cesco-Gaspere Michela, San José Esther, Hart Daniel P, Wong Vivian, Debets Reno, Alarcon Balbino, Morris Emma, Stauss Hans J

Abstract excerpt

We have previously described the functional activity of a human TCR specific for an HLA-A2-presented peptide derived from the Wilms tumor Ag 1 (WT1). Recent studies showed that the expression and function of human TCR was improved by the introduction of an additional disulfide bond between the al...

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Identifiers

PMID: 17947653
DOI: 10.4049/jimmunol.179.9.5803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17947653-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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