Article
Coupling of protein localization and cell movements by a dynamically localized response regulator in Myxococcus xanthus.
The EMBO journal - 31 Oct 2007
Leonardy Simone, Freymark Gerald, Hebener Sabrina, Ellehauge Eva, Søgaard-Andersen Lotte
Abstract excerpt
Myxococcus xanthus cells harbor two motility machineries, type IV pili (Tfp) and the A-engine. During reversals, the two machineries switch polarity synchronously. We present a mechanism that synchronizes this polarity switching. We identify the required for motility response regulator (RomR) as essential for A-motility. RomR localizes in a bipolar, asymmetric pattern with a large cluster at the lagging cell...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- GTP Phosphohydrolases
- Gene Expression Regulation, Bacterial
- Green Fluorescent Proteins
- Models, Biological
- Models, Genetic
- Molecular Sequence Data
- Movement
- Mutation
- Myxococcus xanthus
- Oscillometry
- Phenotype
- Phosphorylation