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Article

An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation.

PloS one - 10 Oct 2007

Yamagishi Satoru, Koyama Yoshihisa, Katayama Taiichi, Taniguchi Manabu, Hitomi Junichi, Kato Masaaki, Aoki Masashi, Itoyama Yasuto, Kato Shinsuke, Tohyama Masaya

Abstract excerpt

Neuronal Lewy body-like hyaline inclusions (LBHI) and astrocytic hyaline inclusions (Ast-HI) containing mutant Cu/Zn superoxide dismutase 1 (SOD1) are morphological hallmarks of familial amyotrophic lateral sclerosis (FALS) associated with mutant SOD1. However, the mechanisms by which mutant SOD1 contributes to formation of LBHI/Ast-HI in FALS remain poorly defined. Here, we report induction of LBHI/Ast-HI-like...

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Identifiers

PMID: 17925878
DOI: 10.1371/journal.pone.0001030
PMCID: PMC2000355

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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