Article
Quantification and phenotypic characterization of circulating tumor cells for monitoring response to a preventive HER2/neu vaccine-based immunotherapy for breast cancer: a pilot study.
Annals of surgical oncology - 1 Dec 2007
Stojadinovic Alexander, Mittendorf Elizabeth A, Holmes Jarrod P, Amin Asna, Hueman Matthew T, Ponniah Sathibalan, Peoples George E
Abstract excerpt
BACKGROUND: Ongoing cancer vaccine trials are limited by the inability of immunologic assays to monitor clinically relevant surrogates of response. Recent advances in the ability to quantify and phenotype circulating tumor cells (CTCs) in breast cancer patients may lead to a role for CTCs in monitoring response to vaccine-based immunotherapy. METHODS: The CellSearch System (Veridex-LLC, Warren, NJ) was used to...
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