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Article

Chloride channel activity of bestrophin mutants associated with mild or late-onset macular degeneration.

Investigative ophthalmology & visual science - 1 Oct 2007

Yu Kuai, Qu Zhiqiang, Cui Yuanyuan, Hartzell H Criss

Abstract excerpt

PURPOSE: Mutations in the hBest1 (VMD2) gene are linked to various kinds of macular degeneration, including Best vitelliform macular dystrophy (BVMD) and adult-onset vitelliform macular dystrophy (AVMD). The age at onset and severity of disease are quite variable. This study was conducted to examine Cl(-) currents generated by six hBest1 mutations (E119Q, A146K, T216I, DeltaI295, D312N, and L567F) found in...

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Identifiers

PMID: 17898294
DOI: 10.1167/iovs.07-0301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chloride channel activity of bestrophin mutants associated with mild or late-onset macular degeneration.PMID 17898294Read ↗

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