Article
The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells.
International journal of cancer - 15 Jan 2008
Kono Tokuyuki, Imai Yasuo, Yasuda Shin-ichi, Ohmori Kyoko, Fukui Hirokazu, Ichikawa Kazuhito, Tomita Shigeki, Imura Johji, Kuroda Yoshikazu, Ueda Yoshihiko, Fujimori Takahiro
Abstract excerpt
Stimulation of the CD155/poliovirus receptor, which localizes in the cell-matrix and at cell-cell junctions, inhibits cell adhesion and enhances cell migration. Necl-5, a mouse homolog of CD155, is implicated in the formation of adherence junctions. Recently, Necl-5 has also been found to enhance cell proliferation via the stimulation of serum and platelet-derived growth factor through the Ras-Raf-MEK-ERK...
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