Article
Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status.
Cancer biology & therapy - 1 Sept 2007
Vrsalovic Maruska Marusic, Pejsa Vlatko, Veic Tajana Stoos, Kolonic Slobodanka Ostojic, Ajdukovic Radmila, Haris Visnja, Jaksic Ozren, Kusec Rajko
Abstract excerpt
Recent observations raise possibility for constitutively active, mutated JAK2 to modulate expression of RAS genes in CMPD. We analyzed the expression of AGT, renin, AT2R1 and ACE genes in normal and bone marrows of PV and ET patients with the respect to the presence of V617F JAK2 mutation. PV and ET had different expression patterns of major RAS components compared to normal BM which was primarily associated with...
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