Article
Characterization of beta-tubulin genes in hookworms and investigation of resistance-associated mutations using real-time PCR.
Molecular and biochemical parasitology - 1 Dec 2007
Schwenkenbecher Jan M, Albonico Marco, Bickle Quentin, Kaplan Ray M
Abstract excerpt
Human hookworms (Ancylostoma duodenale, Necator americanus) are a major cause of malnutrition and anemia, particularly in children, and high worm burdens can lead to stunted growth and mental retardation. Mass drug administration (MDA) with benzimidazole (BZ) anthelmintics has the potential to greatly reduce morbidity and infection prevalence. However, such treatment strategies may apply significant selection...
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